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Cryo–electron microscopy breaks the atomic resolution barrier at last

Posted on October 25, 2020 by Agitator!!

It’s amazing to think that they can pinpoint an individual atom.

If you want to map the tiniest parts of a protein, you only have a few options: You can coax millions of individual protein molecules to align into crystals and analyze them using x-ray crystallography. Or you can flash-freeze copies of the protein and bombard them with electrons, a lower resolution method called cryo–electron microscopy (cryo-EM). Now, for the first time, scientists have sharpened cryo-EM’s resolution to the atomic level, allowing them to pinpoint the positions of individual atoms in a variety of proteins at a resolution that rivals x-ray crystallography’s.

For more, check out this Science story.

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