White adipose tissue, most associated with obesity, is a type of fat that collects in the body for long-term storage of energy. It’s possible humans evolved to store white fat to act as insulation and energy storage. However, as we have become over-fed and less active, we have less need for the energy stored in white fat and it over accumulates, leading to metabolic diseases such as diabetes and obesity...Brown fat is more readily burned by the body, dissipating energy into heat.
In Notch signaling, a cell sends a signal to a neighboring cell to control that neighbor’s gene transcription and its identity. Disrupting that signal in a progenitor cell destined to become one of the undesirable white fat cells leads to the creation of brown fat.